Coenzyme A as growth stimulant for Acetobacter suboxydans.

It had been found that pantothenic acid bound in coenzyme A and its partial degradation products is inactive in the test with Lactobacillus arabinosus.l In this connection a recent report by King, Lecher, and Cheldelin2 was of considerable interest. They isolated from heart muscle a pantothenic acid-containing factor which, with 9. suboxydans, gave a greater and faster growth response than would have been expected from its pantothenic acid content. L. arabinosus did not respond to their preparation, except after decomposition with intestinal phosphatase. The similarity of this factor to coenzyme A was pointed out. In contrast it was found, however, that the preparation did not restore sulfanilamide acetylation and appeared difficultly dialyzable.